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Survivin/CRM1在角膜緣干細胞缺乏類疾病中的表達及GDNF對其修復再生調控的機理研究

時間:2021-05-04 10:47來源:廈門眼科中心編輯:huang瀏覽:

【文章導讀】本研究將評估GDNF、Survivin和CRM1維持和調控角膜上皮干細胞的增殖的作用機制,分析并闡明正常及病變組織中表達變化和特點及Wnt信號通路活化情況。嘗試通過外源性GDNF體外治療LSCD疾病


  本研究將評估GDNF、Survivin和CRM1維持和調控角膜上皮干細胞的增殖的作用機制,分析并闡明正常及病變組織中表達變化和特點及Wnt信號通路活化情況。嘗試通過外源性GDNF體外治療LSCD疾病有助于驗證其可行性,并有望開發新的以Survivin/CRM1為靶點的滴眼液作為臨床治療產品。

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